Strategic Collaboration with AstraZeneca
Cellectis announced the start of R&D activities for three programs under their collaboration with AstraZeneca, including allogeneic CAR T for hematological malignancies, solid tumors, and an in vivo gene therapy. AstraZeneca completed an additional equity investment of $140 million, owning approximately 44% of Cellectis' share capital.
Financial Strength and Cash Runway
Cellectis' cash, cash equivalents, restricted cash, and fixed term deposits amounted to $264 million as of December 31, 2024, up from $156 million in 2023. The company is confident that their cash runway will fund operations into mid-2027.
UCART22 and UCART20x22 Progress
Cellectis received Orphan Drug Designation and Rare Pediatric Disease designation for UCART22. The company expects to present Phase 1 data for UCART22 in the third quarter of 2025 and for UCART20x22 in late 2025.
Manufacturing and Innovation
Cellectis showcased promising CAR T strategies targeting solid tumors using TALEN gene editing technology, presenting preclinical data at major conferences and publishing articles in scientific journals.