Ozuriftamab Vedotin Fast Track Designation
The CAB-ROR2-ADC ozuriftamab vedotin was granted Fast Track designation by the FDA for treating refractory head and neck cancer, showing promising median duration of response and overall survival rates.
Evalstotug Phase II Melanoma Results
All 8 patients treated with evalstotug plus PD-1 showed tumor reduction, with 4 responders including 3 partial responses and 1 complete response, indicating a potential best-in-class CTLA-4 profile.
Mecbotamab Vedotin Encouraging Findings
Observations in non-small cell lung cancer patients with MK-RAS variants show a median overall survival of 12.6 months and a manageable safety profile, suggesting a potential pan-KRAS strategy.
Financial Improvements and Collaborations
Net loss decreased significantly to $10.6 million from $33.3 million year-over-year, supported by $11 million in collaboration revenue from a worldwide license agreement with Context Therapeutics.