Market CompetitionPotential emerging competition from novel kappa opioid receptor antagonists being developed by Neumora Therapeutics and Johnson & Johnson.
Pipeline Execution RiskIf ADVANCE-2 fails, the stock could decline significantly, raising doubts about AXSM's ability to execute on its pipeline.
Product PerformanceAuvelity performance was relatively flat with week-over-week TRx and NRx growth of +1% and +0%, respectively.