Strong Financial Performance
Record quarterly revenues with DAYBUE sales reaching $96.7 million in Q4, up 11% year-over-year, and full-year sales at $348.4 million, up 97% from 2023. NUPLAZID sales hit $162.9 million in Q4, up 13% year-over-year, with full-year sales at $609.4 million, up 11%.
Pipeline Expansion
Introduction of ACP-711 for essential tremor and the addition of a second indication for ACP-204 in Lewy Body Dementia Psychosis. A broader pipeline with programs spanning neuroscience and rare diseases was disclosed.
Global Expansion Plans
Submission of a marketing application with the European Medicines Agency for trofinetide, anticipating EMA approval in Q1 2026. First DAYBUE sales in Canada expected in Q3 2025 and plans for managed access programs in Europe.
Financial Guidance for 2025
Total revenues expected to be in the range of $1.03 billion to $1.095 billion. DAYBUE U.S. net sales are projected to be between $380 million and $405 million, while NUPLAZID sales are expected to range from $650 million to $690 million.
Strong Cash Position
Ending 2024 with a cash balance of $756 million, up from $438.9 million at the end of 2023, primarily driven by cash flows from operations and the sale of a priority review voucher.