Twist Bioscience and bitBiome collaborate on enzymes for biocatalysis

Twist Bioscience announced the launch of a joint Transaminase Enzyme Screening Kit, which is a curated collection of forty-eight highly diverse transaminase enzymes ready for in-house screening and evaluation.Transaminase enzymes catalyze the transfer of an amine group from an amine donor. Importantly, transaminases have emerged as an exciting option for the synthesis of chiral amines, valuable building blocks for the pharmaceutical industry, offering a potential “green alternative” to conventional synthesis. Pairing Twist Bioscience’s high-capacity synthesis technology with bitBiome’s one-of-a-kind proprietary database or bit-GEM, of over two billion microbe sequences enabled the creation of the innovative Transaminase Enzyme Screening Kit. This kit features a unique set of transaminases that can be used by labs and pharmaceutical companies to efficiently implement improved enzymes for biocatalysis, particularly for the synthesis of active pharmaceutical ingredients APIs . Biocatalysis provides a viable alternative to conventional chemically synthesized processes used in the manufacturing of small molecule pharmaceuticals and other key ingredients. ”