Turnstone Biologics presents two posters on methods for TIL selection at SITC

Turnstone Biologics (TSBX) announced it will be presenting two posters highlighting preclinical data on methods for TIL selection at the Society for Immunotherapy of Cancer, SITC, 39th Annual Meeting being held November 6-10, 2024 in Houston, Texas. Title: Enrichment of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes, TIL, in Gastric Cancer: This study utilized a scaled-down research model of clinical TIL isolation and demonstrated successful TIL expansion from gastric tumors. Title: Overlap Between Circulating and Intratumoral T Cell Repertoire as a Predictor of Neoantigen-Reactive TIL Ex-Vivo Expansion: Using single T cell sequencing, this poster illustrates a manufacturing method tested to enrich TIL in tumor-reactive T cells, the results for which suggest that the degree of baseline TCR overlap between blood and tumor repertoire could help identify patients from which tumor-reactive TIL can be expanded.