ProMIS publishes data on pathogenic proteins as treatment target for ALS

ProMIS Neuroscience announced the publication of supportive preclinical data in the Journal of Biological Chemistry in an article titled, “Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1.” ProMIS is developing antibodies selectively targeting misfolded forms of TDP-43 and SOD1. ALS is a fatal neurodegenerative disease of motor neurons. Toxic aggregates of superoxide dismutase-1 and TAR DNA-binding protein 43 in motor neurons are characteristic of ALS.The study showed that these two proteins interact such that misfolding of TDP-43 leads to misfolding and aggregation of SOD1 in a cell system and promotes motor neuron damage in zebrafish.