ProMIS Neurosciences publishes study highlighting oligomers in journal bioRxiv

ProMIS Neurosciences announced the publication of a paper titled, “Relationship between therapeutic activity and preferential targeting of toxic soluble aggregates by amyloid-beta-directed antibodies,” in the online journal, bioRxiv. The study characterized and compared the binding profile of various amyloid-beta-directed antibodies to monomers, soluble oligomers and insoluble Ab fibrils. The results indicate that selectivity for soluble toxic Ass oligomers may be a driver of clinical efficacy and indicated that PMN310 displayed the greatest degree of oligomer selectivity. “The data in this publication highlight PMN310’s high degree of selectivity for toxic Ab oligomers and its differentiation from other Ab-directed antibodies,” stated Neil Warma, Chief Executive Officer of ProMIS Neurosciences. “We believe that PMN310’s ability to avoid both monomer and plaque binding has the potential to improve efficacy and reduce the risk of amyloid-related imaging abnormalities, a key indicator of edema and microhemorrhage risk associated with plaque binding antibody therapies currently on the market and in development. We look forward to the top-line data readout for our Phase 1a study in the coming months and to advancing PMN310 into a Phase 1b multiple ascending dose study in AD patients.”