Phio Pharmaceuticals prsents data on PH-762 at annual meeting of SID

Phio Pharmaceuticals announced it is presenting data about its lead clinical candidate, PH-762, an INTASYL compound. The data is being presented in three posters at the annual meeting of the Society for Investigative Dermatology, SID, this week in Dallas, Texas. “We’re pleased to present the power of the INTASYL platform and specifically, the applicability of lead compound PH-762 in treating skin carcinomas, to this community dedicated to dermatological research and patient care,” stated Linda Mahoney, Phio‘s SVP of Development. PH-762 is an INTASYL compound that silences PD-1, a protein that inhibits T cells’ ability to kill cancer cells. In a murine model, mPH-762 was well tolerated at the maximum administered dose and treatment with mPH-762 provided robust inhibition of tumor growth. Additionally, intratumoral mPH-762 treatment extended abscopal efficacy to untreated distal tumors in bilateral models. Toxicokinetic studies conducted in marmoset monkeys demonstrated that PH-762, when administered intravenously is well-tolerated, with no detectable cytokine-release associated cytokines found in the plasma.