NextCure announces preclinical data on NC605

NextCure (NXTC) announced the presentation of preclinical data demonstrating that treatment with NC605, a novel anti-Siglec-15 (S15) antibody, resulted in enhanced generation of quality bone with better mechanical properties, in an oral presentation at the Osteogenesis Imperfecta Federation Europe virtual Investigator Meeting on November 15th, 2024. These results demonstrate that NC605 is a highly effective treatment for Osteogenesis Imperfecta, also known as brittle bone disease in a well-established model of disease. Key findings include: In the treated mice, 90% of male oim and 80% of female oim, had no fractures post-sacrifice, compared to 85% and 55% in the control groups, respectively. For the treated oim population, both sexes showed: Increased trabecular and cortical tissue mineral density. Increased cortical bone mineral density. Collectively, all changes resulted in overall enhanced bone quality with better mechanical properties. In contrast, only the treated male oim population showed: Increased trabecular bone volume fraction, including an increase in the number of trabeculae and a decreased separation between trabeculae. Increased cortical thickness. Collectively, the changes resulted in an increase of max load and stiffness, measures of mechanical bone strength.