Mira Pharmaceuticals announces preclinical data on Ketamir-2

MIRA Pharmaceuticals (MIRA) announces new preclinical findings showing that Ketamir-2, a novel oral ketamine analog, achieves 60% greater efficacy than the FDA-approved neuropathic pain treatment gabapentin in reducing chemotherapy-induced pain. The study used the paclitaxel model, where neuropathic pain was induced in mice through the administration of PTX, a common chemotherapy drug. While effective in treating cancer, PTX often causes nerve damage, leading to chemotherapy-induced neuropathy characterized by pain, numbness, and tingling. To assess Ketamir-2’s efficacy, mice received PTX every other day for four doses, and pain sensitivity was measured using the Von Frey filament test. On Day 9, at the optimal dose of 300 mg/kg, Ketamir-2 led to near-complete normalization of pain sensitivity, outperforming FDA-approved gabapentin by 60%, which provided only moderate relief. The company will present these findings, along with data from previous studies, at the upcoming Pain Therapeutics Summit in Boston on October 28-29, 2024, to showcase Ketamir-2’s therapeutic potential to the medical community. This presentation emphasizes MIRA’s commitment to sharing its data with the broader scientific community and engaging with key opinion leaders to discuss the significance of these findings.