Jefferies downgraded Marinus Pharmaceuticals (MRNS) to Hold from Buy with a price target of 50c, down from $5. The company’s Phase III study of oral ganaxolone in tuberous sclerosis complex rare-epilepsy failed to meet the primary endpoint of seizure reduction, the analyst tells investors in a research note. The firm sees no near-term catalysts in 2025, driving the downgrade to Hold.
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