Lexicon (LXRX) Pharmaceuticals announced a new analysis of its Phase 3 SCORED clinical trial demonstrating the protective effects of sotagliflozin in patients with diabetic kidney disease, DKD. Data will be presented at Kidney Week 2024, the annual meeting of the American Society of Nephrology in San Diego, California. Details for the presentation are as follows: Within the entire cohort of 10,574 participants, a placebo-adjusted acute decline in eGFR of -2.59 ml/min/1.73m2/year was observed. The total placebo-adjusted slope was -0.08 ml/min/1.73m2/year. Compared to placebo, sotagliflozin had a greater benefit on chronic slope with increasing baseline albuminuria.
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