Kymera Therapeutics presents data for KT-621 at EADV Congress

Kymera Therapeutics announced the presentation of preclinical data for KT-621, a potent, selective, oral degrader of STAT6, an essential transcription factor that is a central driver of TH2 inflammation. The featured data highlight the differentiated profile of KT-621 as a potential once daily, oral treatment for TH2 driven allergic and atopic diseases. The data were presented at the European Academy of Dermatology and Venereology, EADV, Congress being held September 25-28, 2024, in Amsterdam, Netherlands. The Company has completed IND-enabling studies and intends to initiate Phase 1 testing for KT-621 in the second half of 2024, with data from the Phase 1 trial expected to be reported in the first half of 2025. KT-621 demonstrated strong degradation of STAT6 in human sensory neurons resulting in inhibition of IL-13-induced itch- and pain-related gene transcripts with the potential to alleviate these symptoms in atopic dermatitis patients