Kronos Bio to present preclinical data from p300 KAT inhibitor program

Kronos Bio will present preclinical data from its p300 KAT inhibitor program for autoimmune indications at the American College of Rheumatology’s annual meeting, ACR Convergence 2024, being held from November 14 to 19, 2024 in Washington, DC. Kronos Bio is exploring the utility of a p300 KAT inhibitor for autoimmune indications given the role of interferon regulatory factor 4 and p300 in B cells, T cells and other immune cells. The data being presented at the meeting support the role of p300 in inflammation, and the Company remains on track to announce a development candidate for autoimmune diseases by the end of 2024. “We are leveraging our proprietary discovery engine that decodes complex transcription factor regulatory networks to develop a p300 KAT inhibitor to potentially treat autoimmune diseases. We are highly encouraged by these initial data demonstrating that p300 KAT inhibition can modulate the activity and function of multiple pro-inflammatory signaling pathways in chronic inflammatory diseases at well tolerated in vivo exposures,” said Peter Rahl, Ph.D., vice president of Discovery Biology at Kronos Bio, and corresponding author of the abstract. “The multifaceted and multicellular nature of autoimmune diseases suggests that an orally available therapeutic that selectively inhibits pro-inflammatory transcription in multiple cell types may address a root cause of inflammation.”