Jaguar Health to present data on crofelemer for CTD in breast cancer patients

Jaguar Health’s (JAGX) Napo Pharmaceuticals announced that the data from the recently conducted analysis of the prespecified subgroup of adult patients with breast cancer from the Phase 3 OnTarget trial, which indicate that crofelemer achieved significant results in this subgroup, will be the subject of a poster presentation on December 11, 2024 during the 12:30 – 2:00 p.m. CST Poster Session 1 at the San Antonio Breast Cancer Symposium, which takes place December 10-13, 2024 in San Antonio, Texas. Patients with breast cancer accounted for the majority of participants in this unprecedented prophylactic clinical trial recently conducted by Napo for diarrhea in adult patients with solid tumors receiving targeted therapy with or without standard chemotherapy. “We look forward to this presentation at SABCS. A full study report on the breast cancer subgroup analysis is expected to be submitted to a peer-reviewed journal,” said Lisa Conte, Jaguar’s president and CEO. “The content of the presentation will serve as the basis of the briefing package we plan to submit to the U.S. Food and Drug Administration to request a meeting to discuss possible pathways to make crofelemer available as efficiently as possible to breast cancer patients. Additional analyses of OnTarget prespecified subgroups are ongoing, and we believe data from additional analyses may result in future submissions to peer-reviewed forums.” As previously announced, the initial top line results from the OnTarget study showed that the multicenter, double-blind, placebo-controlled pivotal clinical trial did not meet its primary estimand for the prespecified analysis of all tumor types. The subgroup analysis in adult breast cancer patients indicates that crofelemer achieved significant results in this subgroup. A second poster presentation related to the OnTarget trial, based on data from the placebo arm of the study, will also take place during Poster Session 1 at SABCS on December 11, 2024.