Jaguar Health to present crofelemer results at SABCS

Jaguar Health (JAGX) announced that the late-breaking abstract about the recently completed analysis of the prespecified subgroup of adult patients with breast cancer from the Phase 3 OnTarget trial, which indicates that crofelemer achieved significant results in this subgroup, has been accepted for a poster presentation on December 11, 2024 at the San Antonio Breast Cancer Symposium. Patients with breast cancer accounted for the majority of participants in this unprecedented prophylactic clinical trial recently conducted by Napo for diarrhea in adult patients with solid tumors receiving targeted therapy with or without standard chemotherapy. “We are thrilled that this important abstract has been accepted for presentation at SABCS. A full study report on the breast cancer subgroup analysis will be presented at the meeting and is expected to be submitted to a peer-reviewed journal,” said Lisa Conte, Jaguar’s president and CEO. “The content of the abstract will serve as the cornerstone of the briefing package we plan to submit to the U.S. Food and Drug Administration to request a meeting to discuss possible pathways to make crofelemer available as efficiently as possible to breast cancer patients. Additional analyses of OnTarget prespecified subgroups are ongoing, and we believe data from additional analyses may result in future submissions to peer-reviewed forums.”The lead author of the abstract, and the National Principal Investigator of the OnTarget trial, is Pablo C. Okhuysen, MD, FACP, FIDSA, Professor, Department of Infectious Diseases, Infection Control and Employee Health at MD Anderson Cancer Center at the University of Texas in Houston. Other key authors of the abstract include Pravin Chaturvedi, PhD, Chair of Napo’s Scientific Advisory Board and Jaguar’s Chief Scientific Officer; Napo SAB member Lee Schwartzberg, M.D., FACP, Chief of Medical Oncology at Renown Health in Reno, Nevada; Napo SAB member Eric Roeland, MD, FAAHPM, FASCO, Associate Professor of Medicine, Division of Hematology/Medical Oncology, School of Medicine, Oregon Health & Science University; Napo SAB member Stacey Tinianov, MPH, a Board Certified Patient Advocate; Napo SAB member Dr. Kelly Shanahan, a former clinician and a metastatic breast cancer patient who is now a full-time independent patient advocate; as well as two key advisors to Napo: Enoch Bortey and James Bolognese. A second late-breaking abstract related to the OnTarget trial, based on data from the placebo arm of the study, has also been accepted for a poster presentation on December 11, 2024 at SABCS.