Innovation Pharmaceuticals Brilacidin antifungal research published

Innovation Pharmaceuticals announced publication of Brilacidin antifungal research in Nature Communications, a leading peer-reviewed scientific journal. To date, Brilacidin has demonstrated varying degrees of antifungal activity, both in vitro and in vivo, in 14 of 19 "priority" fungal pathogens identified by the World Health Organization, with research ongoing in collaboration with NIH/NIAID-affiliated researchers and other academic groups. "There is a critical need for new antifungal agents," commented Gustavo H. Goldman, Professor of Molecular Biology, at the University of Sao Paulo, Brazil, and a Chief Editor for Frontiers in Fungal Biology. "The clinical utility of currently available antifungal treatments is limited due to emerging drug resistance, toxicity, fungistatic and not fungicidal properties, as well as drug interaction concerns. Brilacidin’s ability to potentiate marketed antifungals, such as caspofungin, in multiple human pathogenic fungi, while showing strong stand-alone potency against the hard-to-treat fungal pathogen, C. neoformans, clearly supports Brilacidin’s potential to be developed as a novel antifungal. Myself, along with team members, are looking forward to exploring Brilacidin’s direct antifungal activity and possible favorable modulation of the host response following infection."