Fractyl Health (GUTS) presented the poster, “Duodenal Mucosal Resurfacing Durably Maintains Weight Loss in Metabolic Disease,” on Sunday, November 3, 2024, during The Obesity Society’s Annual Meeting at ObesityWeek 2024 in San Antonio, Texas. The poster showcased compelling results of a pooled data analysis from five clinical studies, n=118, where participants were followed for 48 weeks post-Revita procedure. At baseline, prior to treatment, participants had longstanding, inadequately controlled T2D. The results still show that 90% of patients lost weight at one-month post-procedure; 84% of these patients maintained their body weight loss through one year of follow-up, even in the absence of any prescribed diet or lifestyle intervention. The early body weight loss after a single Revita procedure, with a durable weight loss plateau reached after week four, represents a differentiated therapeutic time-action profile compared to current obesity drugs, which require prolonged dose titration and ongoing persistence to achieve weight loss. The procedure was well tolerated without any device or serious adverse events observed.
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