Eli Lilly (LLY) announced “positive results” from the TRAILBLAZER-ALZ 6 Phase 3b study, showing a reduction in amyloid-related imaging abnormalities with edema/effusion at the 24-week primary endpoint for people receiving a slightly modified titration of donanemab in adults with early symptomatic Alzheimer’s disease. The primary endpoint of the study was the proportion of participants with any occurrence of ARIA-E by week 24, and the results showed the incidence of ARIA-E was 14% in patients receiving the modified titration compared with 24% for those receiving the standard dosing regimen, a 41% lower relative risk. The largest ARIA-E reduction with the modified titration was seen in apolipoprotein E homozygotes, carriers of a known genetic risk factor for developing Alzheimer’s disease. In these patients, 19% had ARIA-E on the modified titration as compared to 57% on the standard dosing regimen, resulting in a 67% lower relative risk. Lilly is discussing the results of this study with global regulators, with the intent to submit for a potential label update for Kisunla.
Don't Miss our Black Friday Offers:
- Unlock your investing potential with TipRanks Premium - Now At 40% OFF!
- Make smarter investments with weekly expert stock picks from the Smart Investor Newsletter
Published first on TheFly – the ultimate source for real-time, market-moving breaking financial news. Try Now>>
Read More on LLY:
- Boeing to offer 90M common shares, Philips reports mixed Q3: Morning Buzz
- Eli Lilly tells Bloomberg approval received to launch Mounjaro in Hong Kong
- Eli Lilly, ViaNautis sign collaboration agreement for polyNaut platform
- Options Volatility and Implied Earnings Moves This Week, October 28 – November 01, 2024
- Apogee Therapeutics price target raised to $100 from $81 at BTIG