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Dupixent CRL ‘unfortunate’ for Regeneron, but TD Cowen sees path forward

TD Cowen analyst Tyler Van Buren notes that Regeneron (REGN) and Sanofi (SNY) announced that the FDA issued a Complete Response Letter, or CRL, for Dupixent’s sBLA in chronic spontaneous urticaria, or CSU, ahead of the October 22 PDUFA date, which the analyst calls “unfortunate, but not terribly surprising” given that one of the two studies used to support the filing did not succeed. The firm sees a path forward, however, as the ongoing Study C, which is similar to the successful Study A, will have to be used to support refiling of the application, assuming the topline data in Q4 of 2024 are successful. The firm, which thinks Dupixent should eventually be approved and used in CSU, has an Outperform rating and $885 price target on Regeneron shares.

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