Bionano Genomics (BNGO) announced a publication in Modern Pathology by a group of researchers at the Johns Hopkins University School of Medicine, showing that optical genome mapping, OGM, can outperform traditional techniques in analysis of bone and soft tissue tumors. Several prior publications have shown the utility of OGM compared to traditional cytogenetics in studies of hematologic malignancies, however, data on the application of OGM in solid tumors has been relatively sparse. This study provides compelling support for extending the utility of OGM in cancer beyond hematologic malignancies to solid tumors. Key findings: OGM detected all variants revealed by conventional cytogenetics; OGM detected pathogenic variants missed by karyotyping: In 74% of cases with normal or failed karyotype; OGM resolved complex cancer genomes; OGM combined with NGS found pathogenic variants in 98% of cases; OGM findings have the potential to qualify subjects for targeted therapies that otherwise would not have been possible.
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