Biomea Fusion to unveil ew icovamenib data at ATTD 2025

Biomea Fusion (BMEA) announced that it will feature two oral presentations, one poster presentation, and chair a symposium at the 18th International Conference on Advanced Technologies & Treatments for Diabetes. The conference will be held in Amsterdam, Netherlands, from March 19-22, 2025 and serves as a premier international forum showcasing cutting-edge advancements in diabetes care among clinicians, researchers, industry leaders, and policymakers. Biomea’s presentations at ATTD 2025 will showcase preclinical data evaluating the combination of icovamenib with GLP-1 receptor agonists, as well as new clinical findings from the Expansion Phase of the COVALENT-111 study. These data further support the potential of covalent menin inhibition to enhance beta cell function and provide sustained improvements in glycemic control for patients with type 2 diabetes even 14 weeks after cessation of the icovamenib treatment. Additionally, new insights into beta cell function and c-peptide secretion will be presented, offering deeper understanding of icovamenib’s potential to restore endogenous insulin production in people with T2D. Previous findings have demonstrated that 12 weeks of icovamenib treatment resulted in statistically significant HbA1c reductions among study participants with insulin deficient T2D who were uncontrolled on standard-of-care therapies. Severe insulin deficient T2D remains one of the most critical unmet medical needs, affecting more than 100 million adults worldwide. The ATTD 2025 presentations will further elucidate icovamenib’s mechanism of action, reinforcing its potential as a first-in-class, disease modifying therapy.