Athira Pharma completes first cohort in Phase 1 trial of ATH-1105

Athira Pharma announced that it has completed the first cohort of healthy volunteers in its ongoing, first-in-human, dose escalation Phase 1 clinical study evaluating ATH-1105, an oral, small molecule positive modulator of the neurotrophic hepatocyte growth factor system in development for the treatment of amyotrophic lateral sclerosis. “We are particularly excited about the potential for ATH-1105 as a treatment for ALS based on our compelling preclinical data that have shown ATH-1105 can improve motor function, preserve nerve health and structure, and prolong survival in a mouse model of ALS,” said Javier San Martin, M.D., Chief Medical Officer of Athira. “We look forward to continued development of this promising therapeutic candidate for people with ALS, who are in need of therapies that improve the course of disease.”