Assembly Biosciences nominates ABI-6250 to progress to IND-enabling studies

Assembly Biosciences announced the selection of development candidate ABI-6250 to progress to IND-enabling studies. ABI-6250, an orally bioavailable small molecule entry inhibitor, is the first development candidate nominated by the company for the treatment of chronic hepatitis D virus infection, and the second development candidate selected in 2023, following ABI-5366 for high-recurrence genital herpes. “We’re pleased to nominate ABI-6250 as a development candidate targeting chronic HDV infection, the most severe form of viral hepatitis,” said William Delaney, PhD, chief scientific officer of Assembly Bio. “Current treatment options for HDV patients are limited and the only approved therapeutic requires daily injections. We are excited to bring ABI-6250 forward into IND-enabling studies with the goal of providing the first oral chronic therapy for HDV patients.”