Aptevo Therapeutics announces presentation at PEGS conference

Aptevo Therapeutics announced a presentation at The Essential Protein & Antibody Engineering Summit conference in Boston MA. The session, being offered today, Tuesday May 14, 2023 at 8:30 AM Eastern time and entitled “Development of Target Activated ADAPTIRs for Tumor Immunotherapy,” will be led by Dr. Peter Pavlik, PhD, Senior Director of Protein Engineering at Aptevo and will focus on the strategic deployment of early functional screening of a diverse group of binding domains against a given target, combined with screening in multiple possible final formats to elicit varied functional activity, exemplified by preclinical and clinical data supporting predictive outcomes. Aptevo continues to add to a growing body of clinical evidence that supports the preclinical predications of safety, conditional activation, and clinical activity of its portfolio of assets. Recent news from the Company’s two clinical programs includes: A heavily pretreated breast cancer patient, enrolled in the ALG.APV-527 Phase 1 open-label, multi-center, multi-cohort trial for the treatment of multiple solid tumor types, entered the trial and improved from progressive disease to long-lasting stable disease while on therapy. The patient has remained on study for more than eleven months and been successfully transitioned to a higher dose level, with no new adverse events since the transition, which may allow for increased clinical benefit. The trial is more than 50% enrolled and we are dosing cohort 5. The Company is on track to initiate part 1 of its upcoming dose optimization trial in 2Q 2024. The study will further evaluate APVO436 for the treatment of acute myeloid leukemia. Aptevo has partnered with premier CRO, Prometrika, for the upcoming study. The first part is a dose optimization trial evaluating standard of care venetoclax + azacitidine along with APVO436 as a frontline treatment for AML patients. It is planned as an open-label, multi-center, multi-cohort study. The trial will evaluate safety/tolerability and efficacy of the triplet combination at multiple dose levels.