Allurion Technologies to initiate Allurion Balloon with GLP-1 agonists study

Allurion Technologies (ALUR) announced its intention to initiate a clinical study on the combination of the Allurion Balloon with GLP-1 agonists. The study will focus on combination use of the Allurion Balloon with lower dose GLP-1s with the goal of demonstrating improved long-term tolerability and adherence to GLP-1 therapy. Previous studies have shown that 30% of patients discontinue GLP-1 therapy within the first month and 58% discontinue before reaching a clinically meaningful health benefit, due in part to side effects, dose escalation required for continued weight loss, and cost. Studies have previously demonstrated successful use of the Allurion Balloon in combination with short-term use of GLP-1 agonists. In a randomized, double-blind study, published in Obesity Surgery, patients treated with the Allurion Balloon in combination with oral semaglutide demonstrated enhanced weight loss and co-morbidity resolution at four months compared to Allurion Balloon therapy alone.