BioCryst Begins Phase 1 Trial for Netherton Syndrome Treatment

BioCryst ( (BCRX) ) has issued an update.

BioCryst Pharmaceuticals has commenced a significant Phase 1 trial for BCX17725, a promising KLK5 inhibitor, targeting the treatment of Netherton syndrome—an unmet medical need affecting the skin and immune system. This therapeutic is the company’s maiden protein therapeutic candidate advancing to clinical trials, with hopes to transform the treatment landscape for this ultra-rare and life-threatening genetic disorder. Initial trial results are anticipated by the end of 2025, providing a beacon of hope for those suffering from Netherton syndrome.

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